{"id":9894,"date":"2022-06-17T08:50:07","date_gmt":"2022-06-17T08:50:07","guid":{"rendered":"https:\/\/www.booksofall.com\/tw\/?post_type=product&#038;p=9894"},"modified":"2022-06-17T08:50:07","modified_gmt":"2022-06-17T08:50:07","slug":"the-alzheimers-enigma","status":"publish","type":"product","link":"https:\/\/www.booksofall.com\/tw\/the-alzheimers-enigma\/","title":{"rendered":"The Alzheimer\u2019s enigma"},"content":{"rendered":"<h4 id=\"standfirst\" class=\"article__standfirst\">The cause of Alzheimer\u2019s disease has troubled the science world\u2019s best detectives. Michael Regnier asks: can such a mystery really be solved if we gather enough clues?<\/h4>\n<p>The King of Crete demanded that, to atone for the death of his son, the city of Athens send him seven young men and seven young women every seventh year. When they arrived in Crete, they were sent into the Labyrinth, at the centre of which lived the Minotaur, a monstrous creature with the body of a man but the head of a bull. If the Minotaur didn\u2019t kill the young Athenians, they were condemned to wander the tortuous maze, losing first their way and eventually their lives.<\/p>\n<p>This human tribute had been paid twice when Theseus, a prince of Athens, took his place among the 14 youths. In most retellings of the myth, it is taken for granted that the hero will defeat the Minotaur in combat. But the physical fight is not the point of this story \u2013 it\u2019s how Theseus overcame the mental challenge of navigating the Labyrinth. As well as his sword, he took with him a ball of thread, a\u00a0<em>clew<\/em>, to line his path. No matter how deep into the maze he had to go, the thread would bring him out safely.<\/p>\n<p>Theseus\u2019s clew is the root of the modern English word clue, and clues are the best way to solve a mystery. They are signposts showing that a puzzle, no matter how convoluted it seems, has a straightforward solution. Real life is messier than myth or fiction, but we still tend to believe that our problems can be reduced to something manageable, if we only gather enough clues.<\/p>\n<h4>Reference:<\/h4>\n<ul>\n<li>For a broad scientific review of our current understanding (and gaps in understanding) of Alzheimer\u2019s disease, this 2012 review by\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3319071\/\">Yadong Huang and Lennart Mucke in\u00a0<em>Cell<\/em><\/a>\u00a0is really thorough.<\/li>\n<li>Two reviews written in 2006 (to mark the centenary of Alzheimer\u2019s first description of the disease) chart its scientific history: one is by\u00a0<a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0896627306007239\">John Hardy in\u00a0<em>Neuron<\/em><\/a>, the other by\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17082447\">Michel Goedert and Maria Grazia Spillantini in\u00a0<em>Science<\/em><\/a>.<\/li>\n<li><a href=\"http:\/\/books.google.co.uk\/books\/about\/The_Mystery_to_a_Solution.html?id=jsxTenuOQKgC&amp;redir_esc=y\"><em>The Mystery to a Solution<\/em>\u00a0by John T Irwin<\/a>\u00a0(1994) was my guidebook to the labyrinthine connections between Edgar Allan Poe, Jorge Luis Borges and the rest of detective fiction.<\/li>\n<li><em>The Murders in the Rue Morgue<\/em>\u00a0(1841) and\u00a0<em>The Purloined Letter<\/em>\u00a0(1844) can be found in many collections of Poe\u2019s work;\u00a0<em>The Mystery of Marie Rog\u00eat<\/em>\u00a0(1842) is harder to find in print\u00a0<a href=\"http:\/\/xroads.virginia.edu\/~hyper\/poe\/m_roget.html\">but it is online<\/a>.<\/li>\n<li>Similarly, more than one collection of Borges\u2019s work includes\u00a0<em>The Garden of Forking Paths<\/em>\u00a0(1941) and\u00a0<em>Death and the Compass<\/em>\u00a0(1942);\u00a0<em>Ibn-Hakam al-Bokhari, Murdered in His Labyrinth<\/em>\u00a0(1951) can be found in\u00a0<a href=\"http:\/\/books.google.co.uk\/books\/about\/Aleph_and_other_stories.html?id=XYZlAAAAMAAJ&amp;redir_esc=y\"><em>The Aleph and Other Stories<\/em><\/a>, published by Penguin.<\/li>\n<li>Information about Alzheimer\u2019s disease is available from the UK\u2019s two biggest dementia charities \u2013\u00a0<a href=\"http:\/\/www.alzheimersresearchuk.org\/\">Alzheimer\u2019s Research UK<\/a>\u00a0and the\u00a0<a href=\"http:\/\/www.alzheimers.org.uk\/\">Alzheimer\u2019s Society<\/a>\u00a0\u2013 and from the\u00a0<a href=\"http:\/\/www.alz.org\/\">Alzheimer\u2019s Association<\/a>\u00a0in the USA.<\/li>\n<li>An article by\u00a0<a href=\"http:\/\/www.theatlantic.com\/health\/archive\/2014\/01\/why-cant-we-prevent-alzheimers\/283256\/\">Jim Kozubek in the\u00a0<em>Atlantic<\/em><\/a>\u00a0earlier this year looked at some more recent ideas in Alzheimer\u2019s disease research.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p><iframe style=\"width: 100%; height: 750px; border: none;\" src=\"https:\/\/online.visual-paradigm.com\/share\/book\/the-alzheimers-enigma-zo5fxp4f5?enforceShowPromotionBar=true\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n","protected":false},"featured_media":9906,"template":"","meta":{"_yoast_wpseo_title":"","_yoast_wpseo_metadesc":"Intuitive online diagram maker - Learn how to add line breaks into shapes created using Visual Paradigm's free online diagram editor."},"product_brand":[],"product_cat":[15,222],"product_tag":[],"class_list":{"0":"post-9894","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-all","7":"product_cat-anthropology","9":"first","10":"instock","11":"shipping-taxable","12":"product-type-simple"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>The Alzheimer\u2019s enigma - BooksOfAll Traditional Chinese<\/title>\n<meta name=\"description\" content=\"Intuitive online diagram maker - Learn how to add line breaks into shapes created using Visual Paradigm&#039;s free online diagram editor.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.booksofall.com\/tw\/the-alzheimers-enigma\/\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The Alzheimer\u2019s enigma - 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