{"id":9125,"date":"2022-06-15T02:28:59","date_gmt":"2022-06-15T02:28:59","guid":{"rendered":"https:\/\/www.booksofall.com\/?post_type=product&#038;p=9125"},"modified":"2022-06-15T02:29:55","modified_gmt":"2022-06-15T02:29:55","slug":"the-experimental-diet-that-mimics-a-rare-genetic-mutation","status":"publish","type":"product","link":"https:\/\/www.booksofall.com\/pt\/the-experimental-diet-that-mimics-a-rare-genetic-mutation\/","title":{"rendered":"The experimental diet that mimics a rare genetic mutation"},"content":{"rendered":"<h4 id=\"standfirst\" class=\"article__standfirst\">Peter Bowes has been on a new diet that claims to guard against disease and slow ageing. Then he met a group with a mutation that lets them eat what they want while enjoying the same protection.<\/h4>\n<aside class=\"article__aside\">\n<div class=\"article__aside__section article__share-buttons\" role=\"group\">\n<p>With the help of a small stool, Mercy Carrion clambers onto an examination table. The obese 50-year-old woman stands just 115.6 cm (3\u20199.5\u2019\u2019) tall. Despite being overweight, Mercy shows no sign of developing diabetes and has remarkably low blood pressure at 100\/70. \u201cThat\u2019s why they don\u2019t care much about their weight,\u201d says her doctor, Jaime Guevara-Aguirre.<\/p>\n<p>Mercy, who has a rare genetic disorder, is one of his long-term patients. She and her peers know they are in some way protected from diabetes, cancer and a number of other diseases that threaten the rest of us as we age. As such, they have a happy-go-lucky attitude towards health and fitness.<\/p>\n<p>Mercy giggles as she tells her doctor that dieting is not her. She enjoys a typical high-calorie Ecuadorian diet, where rice accompanies almost every meal. The next day, we visit her at home in a poor, farming community in El Oro province, a one-hour flight away. Her refrigerator is stocked with red meats, bologna and eggs. Bananas are plentiful, and usually served fried.<\/p>\n<p>This high calorie-diet contributes to her excess weight. But, paradoxically, the biology that has driven her weight gain could also be what protects her from disease. I\u2019m fascinated, partly because this woman\u2019s condition relates so much to a diet I\u2019ve been trying for the past three years.<\/p>\n<p>Actually, it is somewhat misleading to call it a \u2018diet\u2019. It certainly leads to short-term weight loss, but researchers prefer to see it as an investment in the future. It could, they say, start a regenerative process that will lead to improved health and longer life. If the theory stands, I could enjoy a lower risk of cancer, a strengthened immune system, improved cognitive ability and little to no chance of contracting diabetes.<\/p>\n<p>I signed up to it three years ago as part of an intriguing clinical trial at the University of Southern California, Los Angeles. It involved reducing my calories by up to two-thirds, over five consecutive days, once a month for three months. The rest of the time I ate normally, without restrictions. Three years on, I have just completed my tenth Fasting Mimicking Diet.<\/p>\n<p>The science is based on years of experimentation with yeast, worms, flies, mice \u2013 and studies of Ecuadorians with a form of dwarfism.<\/p>\n<h4>Reference:<\/h4>\n<ul>\n<li><a href=\"http:\/\/www.cell.com\/cell-metabolism\/abstract\/S1550-4131(15)00224-7\">Early results of the 2013 fasting mimicking diet trial<\/a>\u00a0that Peter Bowes took part in as a volunteer.<\/li>\n<li>Zvi Laron and John Kopchick\u2019s book\u00a0<em><a href=\"http:\/\/link.bu.edu\/portal\/Laron-Syndrome---From-Man-to-Mouse--Lessons-from\/W4qb9RZPSwE\/\">From Man to Mouse: Lessons from clinical and experimental experience<\/a><\/em>\u00a0provides a detailed guide to the history of Laron syndrome in humans and mice.<\/li>\n<li>A comprehensive account of the 22-year\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21325617\">study of Ecuadorian people with Laron syndrome<\/a>\u00a0and the laboratory studies that aim to explain why they are protected from cancer and diabetes. By Jaime Guevara-Aguirre and colleagues.<\/li>\n<li>A paper by Valter Longo, Guevara-Aguirre and others focusing on\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25985182\">the link between growth hormone receptor deficiency, obesity and diabetes<\/a>.<\/li>\n<li>A paper co-authored by Longo exploring\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3946160\/\">the extraordinary power of fasting and the link to extending longevity<\/a>.<\/li>\n<\/ul>\n<\/div>\n<\/aside>\n","protected":false},"excerpt":{"rendered":"<p><iframe style=\"width: 100%; height: 750px; border: none;\" src=\"https:\/\/online.visual-paradigm.com\/share\/book\/the-experimental-diet-that-mimics-a-rare-genetic-mutation-zkwtxt5nk?enforceShowPromotionBar=true\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n","protected":false},"featured_media":9143,"template":"","meta":{"_yoast_wpseo_title":"","_yoast_wpseo_metadesc":"You can also create similar flipbook to promote your brand. A flipbook is the exact choice you need to share your brand guidline. Create your flipbook today!"},"product_brand":[],"product_cat":[15,222],"product_tag":[],"class_list":{"0":"post-9125","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-all","7":"product_cat-anthropology","9":"first","10":"instock","11":"shipping-taxable","12":"product-type-simple"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>The experimental diet that mimics a rare genetic mutation - BooksOfAll Portuguese<\/title>\n<meta name=\"description\" content=\"You can also create similar flipbook to promote your brand. A flipbook is the exact choice you need to share your brand guidline. Create your flipbook today!\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.booksofall.com\/pt\/the-experimental-diet-that-mimics-a-rare-genetic-mutation\/\" \/>\n<meta property=\"og:locale\" content=\"pt_PT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The experimental diet that mimics a rare genetic mutation - BooksOfAll Portuguese\" \/>\n<meta property=\"og:description\" content=\"You can also create similar flipbook to promote your brand. A flipbook is the exact choice you need to share your brand guidline. 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