{"id":10606,"date":"2022-06-22T03:56:25","date_gmt":"2022-06-22T03:56:25","guid":{"rendered":"https:\/\/www.booksofall.com\/id\/?post_type=product&#038;p=10606"},"modified":"2022-06-22T03:57:15","modified_gmt":"2022-06-22T03:57:15","slug":"penicillins-first-patient","status":"publish","type":"product","link":"https:\/\/www.booksofall.com\/id\/penicillins-first-patient\/","title":{"rendered":"Penicillin\u2019s first patient"},"content":{"rendered":"<h4 id=\"standfirst\" class=\"article__standfirst\">Uncovering the truth behind the first man treated with the world\u2019s first antibiotic.<\/h4>\n<aside class=\"article__aside\">\n<div class=\"article__aside__section article__share-buttons\" role=\"group\">\n<div class=\"paragraph paragraph--text\">\n<p>he discovery of penicillin by Alexander Fleming in 1928 is often portrayed as a stroke of serendipity falling upon a sloppy worker who had left a bacterial culture plate open on his bench while taking a holiday. The fungus that landed there killed the bacteria \u2013 and the lucky Fleming could claim to have saved the world.<\/p>\n<p>It was no simple fluke. The Scottish doctor had, in fact, been leading research into the quest for antimicrobial agents for many years by this time. Fleming, however, failed to develop the drug, finding it too difficult to purify. This was left to Howard Florey, Ernst Chain and Norman Heatley in Oxford over a decade later \u2013 work catalysed by the necessity of war.<\/p>\n<\/div>\n<div class=\"paragraph paragraph--text\">\n<p>The first patient to be treated with penicillin was a policeman, Constable Albert Alexander. According to popular legend, Alexander developed sepsis after pricking himself while pruning roses in the garden of the police house in the pretty hamlet of Wootton in Oxfordshire in the early autumn of 1940.<\/p>\n<p>By the time the researchers felt they could test penicillin in humans \u2013 having cured infections in mice and proven its safety in a terminally ill human volunteer \u2013 Alexander was deteriorating fast. Now in the Radcliffe Infirmary in Oxford, he was covered in abscesses and had already lost an eye.<\/p>\n<p>He received an initial dose of 200 mg of penicillin, followed by another 300 mg every three hours over five days. His short-term recovery was remarkable. However, the original penicillin formulation was excreted from the body so rapidly that Florey likened their task to trying to fill a bath with the plug out. It also explains the need for frequent repeat doses.<\/p>\n<h4>Reference:<\/h4>\n<ul>\n<li><a href=\"https:\/\/books.google.co.uk\/books\/about\/Penicillin_Man.html?id=ZVd2QgAACAAJ\"><em>Penicillin Man: Alexander Fleming and the antibiotic revolution<\/em><\/a>, by Kevin Brown.<\/li>\n<li>An\u00a0<a href=\"https:\/\/www.pe.com\/2012\/11\/02\/redlands-local-artists-share-childhood-bond\/\">interview with Sheila LeBlanc<\/a>, from the Californian newspaper the<em>\u00a0Press-Enterprise<\/em>.<\/li>\n<li><a href=\"https:\/\/www.acs.org\/content\/acs\/en\/education\/whatischemistry\/landmarks\/flemingpenicillin.html\"><em>Discovery and Development of Penicillin, 1928\u20131945<\/em><\/a>, from the American Chemical Society.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/aside>\n","protected":false},"excerpt":{"rendered":"<p><iframe style=\"width: 100%; height: 750px; border: none;\" src=\"https:\/\/online.visual-paradigm.com\/share\/book\/penicillins-first-patient-zv04q2mx6?enforceShowPromotionBar=true\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n","protected":false},"featured_media":10616,"template":"","meta":{"_yoast_wpseo_title":"","_yoast_wpseo_metadesc":"Create UML diagrams online. See how to create a region inside a UML state shape, using Visual Paradigm's online UML diagram tool."},"product_brand":[],"product_cat":[15,218],"product_tag":[],"class_list":{"0":"post-10606","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-all","7":"product_cat-chemistry","9":"first","10":"instock","11":"shipping-taxable","12":"product-type-simple"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Penicillin\u2019s first patient - BooksOfAll Indonesian<\/title>\n<meta name=\"description\" content=\"Create UML diagrams online. 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